Cytokines Immunology Biology

Cytokines

A large class of glycoproteins similar to lymphokines but produced by non-lymphocytic cells such as normal macrophages, fibroblasts, keratinocytes and a variety of transformed cell lines. The most well known cytokines are the interferon (IFN) and interleukins (IL-1, IL-6). They were discovered through their role in regulating immunological and inflammatory and repair processes. However, they also regulate normal cell growth and differentiation. Cytokines are analagous to hormones in their intercellular regulatory functions at very low concentrations, but are not produced by glands. [see Endocrinology] Hence, some discovered by their action, rather than their chemical structure, have been named Growth_Factors, and yet these function throughout life, eg. to stimulate the endothelial cells to express 'selectins' on the internal surfaces of blood vessels, causing leukocytes to adhere, then be removed from circulation between endothelial cells.

• - Overview of main cytokines engaged in allergic responses and their therapeutic potential in allergic diseases. Maintained by Medical Education Information Center, University of Texas.
  
• - Exploring the future directions in unraveling the roles of local vascular and inflammatory mediators in health and disease and their potential as targets in drug therapy. The meeting to be held in Lund, Sweden on May 26-28, 2005.
  
• - Contains information on neurotrophins, cytokines, growth factors - their main features, receptors and receptor subunits, as well as trophic factor related disorders. Maintained by the Neuromuscular Disease Centre at the Washington University, St.Louis, MO
  
• - A collection of EST (Expressed Sequence Tag) records of cytokines deposited in the NCBI GenBank.
  
• - Studies of the alpha helical cytokine family Interferon-gamma, interferon-alpha, and interleukin-10, their receptors, intracellular signaling molecules with emphasis on understanding the structural basis of molecular recognition events that subsequently l
  
• - Arachidonic acid metabolic pathways. Synthesis of prostanoids, lipoxin and leukotriene.
  
• - Subscription only compendium on cytokines and their receptors, consists of the entire content of the Cytokine FactsBook, published by Academic Press, Elsevier Science.
  
• - Eight topic lectures covering cytokines, their first description, features, philosophy, comparison with hormones, chemokines and the classes of receptor families. Part of the pathology course by Alexander G. Izaguirre at University of Medicine and Dentis
  
• - Technique for bone and tissue regeneration, conceived and developed by BTI Biotechnology Institute. Some of his therapeutical applications are oral, maxillofacial, periodontal surgery and dental implants.
  
• - Contains information on signaling pathways of cytokines for biomedical researchers.
  
• - Aims to provide a forum for all specialties and disciplines with interests in clinical and scientific aspects of cytokine medicine, including recent advances in cytokine biology, recent data from clinical trials in different diseases, the use of cytokine
  
• - A compendium of cytokines and other mediators of host defense. Cytokines structure and function description, gene regulation, in vivo and in vitro activities, diagnostic and therapeutic utilities as well as cytokine classification by family, receptor, nam
  
• - Structure and function of cytokines and their receptors, and their potential therapeutic uses, in treatment of cancer and AIDS, provided by the medical university, Beijing, China.
  
• - The cytokine-interferon open forum, downloadable PDF newsletters, links to conferences, meetings, related websites and journals as well as society matters and membership details along with application forms.
  
• - Offers, for in vitro research use only, recombinant growth factors, cytokines, chemokines and in some case ELISA kits and receptors, including soluble free fraction VEGF-receptor kit, from Flanders, NJ.
  
• - Overview of sarcopenia and potentialities of physical exercise as an prevention method of immunosenescence, correlation between the muscle mass and TNF-alpha:IL-6 ratio.
  
• - Review of main cytokines and their principle activities. Maintained by Faculty of Medicine, Dalhousie University, Canada.
  
• - Cytokines mini-reviews, their applications, cytokine facts and literature, maintained by R&D Systems company.
  
• - Society affairs, members and application details, conferences, downloadable PDF newsletters, links to journals and other resources. Also discussion group, including archive to 1997, and contact list for postdoctoral posts worldwide.
  
• - Overview of regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action.
  
• - Information on main cytokines, pictures regarding cytokine receptor classes, links to signal pathways, internet resources, and slide show about signalling pathways inside the cell, maintained by Institute of Clinical Immunology, FSU Jena, Germany.
  
• - Four abstracts covering the role of cytokines and T-helper cells in multiple sclerosis.
  
• - Forum for the interaction of scientists with a common interest in the immunology, molecular biology and physiology of cytokines, information on mini-symposia by NIH-area scientists dealing with multidisciplinary aspects of cytokine research, as well as m
  
• - Subscription and submission invitation for articles on study and applications of interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, and putative cytokines in the official journal of the International Cytokine Society, published
  
• - Introduction to growth factors and cytokines maintained by Michael W. King at the School of Medicine, Indiana State University, Terre Haute, IN.
  
• - Overview of cytokines, their properties, activities and receptors. Part of immunology course offered by the Department of Veterinary Science and Microbiology at the University of Arizona, USA.
  
• - Promoting collaboration and outsourcing to develop cell culture processes, including proliferation and neutralization bioassays, using their cytokines and growth factors in cell culture media, from manufacturer at Natick, MA.
  
• - Abstract of review of recent developments in cytokine biology that are relevant to clinical psychiatry. The role of cytokines in various brain activities and pathophysiology of specific psychiatric disorders.
  
  

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