Cytokines Immunology Biology

A large class of glycoproteins similar to lymphokines but produced by non-lymphocytic cells such as normal macrophages, fibroblasts, keratinocytes and a variety of transformed cell lines. The most well known cytokines are the interferon (IFN) and interleukins (IL-1, IL-6). They were discovered through their role in regulating immunological and inflammatory and repair processes. However, they also regulate normal cell growth and differentiation. Cytokines are analagous to hormones in their intercellular regulatory functions at very low concentrations, but are not produced by glands. [see Endocrinology]Hence, some discovered by their action, rather than their chemical structure, have been named Growth_Factors, and yet these function throughout life, eg. to stimulate the endothelial cells to express 'selectins' on the internal surfaces of blood vessels, causing leukocytes to adhere, then be removed from circulation between endothelial cells.

• R & D Systems - Cytokine Facts - Cytokines mini-reviews, their applications, cytokine facts and literature, maintained by R&D Systems company.
  
• Cytokine - Subscription and submission invitation for articles on study and applications of interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, and putative cytokines in the official journal of the International Cytokine Society, published
  
• Cytokines at Dalhousie University - Review of main cytokines and their principle activities. Maintained by Faculty of Medicine, Dalhousie University, Canada.
  
• Cytokine Reference - A compendium of cytokines and other mediators of host defense. Cytokines structure and function description, gene regulation, in vivo and in vitro activities, diagnostic and therapeutic utilities as well as cytokine classification by family, receptor, nam
  
• Cytokines, HIV and the Immune System - An overview of the role of cell messengers in HIV infection.
  
• Cytokines in Allergic Disease - Overview of the main cytokines engaged in allergic responses and their therapeutic potential in allergic diseases. Maintained by Medical Education Information Center, University of Texas.
  
• Growth Factors and Cytokines - Introduction to growth factors and cytokines maintained by Michael W. King at the School of Medicine, Indiana State University, Terre Haute, IN.
  
• Cytokines Online Pathfinder Encyclopedia - COPE, claiming over 10,000 entries, over 19,000 references on cytokine research, hyperlinks, with tables, formulae, graphics, and integrated sub-dictionaries on related disciplines. Includes profile of author Prof. Horst Ibelgaufts.
  
• Cytokines 2007 - Cytokines in Health and Disease - 15th Annual Meeting of the International Cytokine Society, October 26-30th, 2007. San Francisco, California.
  
• 8th International Conference on New Trends in Immunosuppression and Immunotherapy - February 14-17, 2008, Berlin, Germany
  
• Structural Biology in the Walter Lab - Studies of the alpha helical cytokine family Interferon-gamma, interferon-alpha, and interleukin-10, their receptors, intracellular signaling molecules with emphasis on understanding the structural basis of molecular recognition events that subsequently l
  
• Research Diagnostics Inc. - Offers, for in vitro research use only, recombinant growth factors, cytokines, chemokines and in some case ELISA kits and receptors, including soluble free fraction VEGF-receptor kit, from Flanders, NJ.
  
• Cytokines and Psychiatry - Abstract of review of recent developments in cytokine biology that are relevant to clinical psychiatry. The role of cytokines in various brain activities and pathophysiology of specific psychiatric disorders.
  
• Cytokines in asthma - Cytokines and their role in the development of chronic inflammation in asthma
  
• Neurotrophic Factors - Information and links about nerve growth factors.
  
• The International Cytokine Society - Provides membership details, conference calendar, newsletters and resources.
  
• Cytokines and Mood - Mood and cognitive disorders in cancer patients receiving cytokine therapy. Abstract.
  
• Cytokine Interest Group - Forum for the interaction of scientists with a common interest in the immunology, molecular biology and physiology of cytokines, information on mini-symposia by NIH-area scientists dealing with multidisciplinary aspects of cytokine research, as well as m
  
• 3rd International Conference on Cytokine Medicine - Aims to provide a forum for medical and scientific aspects, including recent advances and data from clinical trials in different diseases, delivery and monitoring. Two day meeting held in London, UK.
  
• SBH Sciences - Promoting collaboration and outsourcing to develop cell culture processes, including proliferation and neutralization bioassays, using their cytokines and growth factors in cell culture media, from manufacturer at Natick, MA.
  
• The International Society for Interferon and Cytokine Research - The cytokine-interferon open forum, downloadable PDF newsletters, links to conferences, meetings, related websites and journals as well as society matters and membership details along with application forms.
  
• Cytokine Webfacts - Subscription only compendium on cytokines and their receptors, consists of the entire content of the Cytokine FactsBook, published by Academic Press, Elsevier Science.
  
• Trophic factors - Contains information on neurotrophins, cytokines, growth factors - their main features, receptors and receptor subunits, as well as trophic factor related disorders. Maintained by the Neuromuscular Disease Centre at the Washington University, St.Louis, MO
  
• Cytokine Family Database - A collection of EST (Expressed Sequence Tag) records of cytokines deposited in the NCBI GenBank.
  
• Cytokines, Cytokine Signaling and Cancer - Researchers at the Cancer Institute of New Jersey are studying cytokines, signal transduction systems, the effects of cytokines on the host and how these may be manipulated for the treatment and prevention of cancer.
  
• Cytokine Information Database - Developed to provide information about the involvement of cytokine in the immune system and disease pathogenesis.
  
• Cytokines - Overview of cytokines, their properties, activities and receptors. Part of immunology course offered by the Department of Veterinary Science and Microbiology at the University of Arizona, USA.
  
• Cytokines and Inflammation - The Brennan lab is researching cytokine expression and regulation in chronic inflammatory diseases.
  
• ImPRINTS - A sub-site of the PRINTS database aimed to help throughout the structural and functional characterization of the immunological molecules including allergens, cytokines, immunoglobulin superfamily, CD and virulence factors.
  
• Cytokines, Cellular & Molecular Therapy - Collection of academic and professional publications including information on cytokines, cellular and molecular therapy.
  
• Cytokines Web - Structure and function of cytokines and their receptors, and their potential therapeutic uses, in treatment of cancer and AIDS, provided by the medical university, Beijing, China.
  
• PRGF: Plasma Rich in Growth Factors - Technique for bone and soft tissue regeneration, conceived and developed by BTI Biotechnology Institute. Some of the therapeutical applications are oral, maxillofacial, periodontal surgery and dental implants.
  
• Eicosanoids - Arachidonic acid metabolic pathways. Synthesis of prostanoids, lipoxin and leukotriene.
  
• Hormones and Cytokines - Overview of regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action.
  
  

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