Congenital Chloride Diarrhea Inherited Nutrition and Metabolism Disorders Conditions and Diseases

Congenital Chloride diarrhea (CLD) is an intestinal transport defect of chloride ions. Retention of intestinal chloride causes water retention, which leads to watery diarrhea with an abnormally high chloride concentration. This defect presents in utero, with hydramnion presumably due to intrauterine diarrhea. The gestational period is shortened, and newborn babies have abdominal distension and chronic watery diarrhea. If untreated the condition leads to severe electrolyte changes with a fatal outcome, or to permanent damage of kidneys and brain. Treatment with chloride substitution and control of electrolyte balance is effective and patients can live an almost normal life complicated only by relatively loose stools.

• Top/Health/Child Health/Conditions and Diseases/Digestive Disorders
• Top/Regional/Europe/Finland/Health/Conditions and Diseases

• Congenital Chloride Diarrhea - In Gastrointestinal and Liver Physiology Kere et al inherited describe the congenital chloride diarrhea location of the CLD-causing gene.
• Archives of Disease in Childhood - Pictures of newborns showing symptoms of Chloride diarrhea, inherited familial.

   MySQL - Cache Direct